Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

This letter describes an immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of remdesivir. Phylogenetic analysis showed accelerated viral evolution.

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Bibliographic Details
Published in:New England Journal of Medicine 2020-12
Main Authors: Choi, Bina, Choudhary, Manish C, Regan, James, Sparks, Jeffrey A, Padera, Robert F, Qiu, Xueting, Solomon, Isaac H, Hsiao-Hsuan Kuo, Boucau, Julie, Bowman, Kathryn, U. Das Adhikari, Winkler, Marisa L, Mueller, Alisa A, Tiffany Y.-T. Hsu, Desjardins, Michaël, Baden, Lindsey R, Chan, Brian T, Walker, Bruce D, Lichterfeld, Mathias, Brigl, Manfred, Kwon, Douglas S, Kanjilal, Sanjat, Richardson, Eugene T, Jonsson, A Helena, Alter, Galit, Barczak, Amy K, Hanage, William P, Yu, Xu G, Gaiha, Gaurav D, Seaman, Michael S, Cernadas, Manuela, Li, Jonathan Z
Format: Article
Language:English
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Summary:This letter describes an immunocompromised patient who had persistent infection with SARS-CoV-2 over a period of months, despite several courses of remdesivir. Phylogenetic analysis showed accelerated viral evolution.
DOI:10.1056/NEJMc2031364