Simultaneous estimation of halobetasol propionate and tazarotene in pure and dosage form by using uv-visible spectrophotometric method

To decrease or avoiding the adverse effects of Halobetasol like skin roughness, skin dryness, itching, Tazarotene was selected in combination because of its counter effects on the adverse effect of Halobetasol. The mechanism of action of Halobetasol is by diffusing across cell membranes and then its...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2020-10, Vol.13 (10), p.4711-4714
Main Authors: Kumar, Avichal, Goyal, Kamya, Pandit, Vinay, Ashawat, MS, Jindal, Shammy
Format: Article
Language:English
Subjects:
Accuracy
Acne
Calibration
Conflicts of interest
Dermatology
Drugs
Pharmaceuticals
Psoriasis
Skin
Skin diseases
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Summary:To decrease or avoiding the adverse effects of Halobetasol like skin roughness, skin dryness, itching, Tazarotene was selected in combination because of its counter effects on the adverse effect of Halobetasol. The mechanism of action of Halobetasol is by diffusing across cell membranes and then its interaction with receptors known as cytoplasmic corticosteroid, located in dermal cells as well as intradermal cells.1,2 The Tazarotene (Molecular Formula- C21H21NO2S) (Fig. 2) is third generation topical retinoid prescribed in the form of topical gel, cream, lotion etc. The obtained data were processed using MS Excel computer program.7,10,11,12 Linearity: Calibration plots were prepared in various solutions and data were analyzed by applying linear regression analysis. [...]from the above validated parameters and their positive results analysis, we concluded that the developed simultaneous equation method for spectrophotometric analysis of drugs Halobetasol and Tazarotene is best for simultaneously analytical studies.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00829.X