Calystegines are Potential Urine Biomarkers for Dietary Exposure to Potato Products

Scope Metabolites derived from specific foods present in urine samples can provide objective biomarkers of food intake (BFIs). This study investigated the possibility that calystegines (a class of iminosugars) may provide BIFs for potato (Solanum tuberosum L.) product exposure. Methods and results C...

Full description

Saved in:
Bibliographic Details
Published in:Molecular nutrition & food research 2020-10, Vol.64 (20), p.e2000515-n/a
Main Authors: Beckmann, Manfred, Lloyd, Amanda J., Wilson, Thomas, Torres, Duarte P. M., Goios, Ana C. L., Willis, Naomi D., Lyons, Laura, Phillips, Helen, Mathers, John C., Nash, Robert J., Sharp, Hazel, Draper, John
Format: Article
Language:English
Subjects:
Biomarkers
biomarkers of food intake
calystegines
Cooking
Cultivars
Diet
Epidemiology
Exposure
Food
Food intake
Mass spectrometry
Mass spectroscopy
Metabolites
metabolomics
potato exposure biomarker
Potatoes
Quadrupoles
solanaceous
Urine
Vegetables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Scope Metabolites derived from specific foods present in urine samples can provide objective biomarkers of food intake (BFIs). This study investigated the possibility that calystegines (a class of iminosugars) may provide BIFs for potato (Solanum tuberosum L.) product exposure. Methods and results Calystegine content is examined in published data covering a wide range of potato cultivars. Rapid methods are developed for the quantification of calystegines in cooked potato products and human urine using triple quadrupole mass spectrometry. The potential of calystegines as BFIs for potato consumption is assessed in a controlled food intervention study in the United Kingdom and validated in an epidemiological study in Portugal. Calystegine concentrations are reproducibly above the quantification limit in first morning void urines the day after potato consumption, showing a good dose‐response relationship, particularly for calystegine A3. The design of the controlled intervention mimicks exposure to a typical UK diet and showed that neither differences in preparation/cooking method or influence of other foods in the diet has significant impact on biomarker performance. Calystegine biomarkers also perform well in the independent validation study. Conclusion It is concluded that calystegines have many of the characteristics needed to be considered as specific BFIs for potato product intake. Calystegines (a class of iminosugars) concentration shows a good dose‐response relationship in first morning void urines the day after potato consumption in intervention and population studies.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.202000515