The Effect of Extractum Cepae, Heparin Sodium, and Allantoin in Experimental Peritoneal Adhesion

The purpose of the study is to investigate the effects of e xtractum cepae (EC), heparin sodium (HS), and allantoin (AA) on postoperative peritoneal adhesion (PPA) prevention. Forty-eight rats were allocated into six groups ( n  = 8). PPA was performed by Harris method. In group 1, no additional pro...

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Bibliographic Details
Published in:Indian journal of surgery 2020-10, Vol.82 (5), p.892-898
Main Authors: Ozmen, Ismail, Gunal, Yasemin Dere, Atasoy, Pinar, Kisa, Ucler, Yorubulut, Serap, Aslan, Mustafa Kemal, Boybeyi-Turer, Ozlem
Format: Article
Language:English
Subjects:
Abdominal surgery
Anticoagulants
Anticoagulants (Medicine)
Cardiac Surgery
Medicine
Medicine & Public Health
Neurosurgery
Original Article
Pediatric Surgery
Plastic Surgery
Povidone
Proline
Surgery
Surgical outcomes
Surgical techniques
Thoracic Surgery
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Summary:The purpose of the study is to investigate the effects of e xtractum cepae (EC), heparin sodium (HS), and allantoin (AA) on postoperative peritoneal adhesion (PPA) prevention. Forty-eight rats were allocated into six groups ( n  = 8). PPA was performed by Harris method. In group 1, no additional procedure was done. Abdominal cavity was washed with normal saline in group 2, EC in group 3, HS in group 4, AA in group 5, and EC-HS-AA mixture (EHA-m) in group 6. On the 21st postoperative day, PPA was scored with Nair adhesion score and examined for fibrosis histopathologically and hydroxy-proline levels (OHP) biochemically. Macroscopically, PPA was decreased in groups 2, 4, and 6 compared to groups 1, 3, and 5 ( p  
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-020-02176-0