CRYSTALLINE FORMS OF BETULIN: POLYMORPHISM OR PSEUDOPOLYMORPHISM?

By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemih...

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Bibliographic Details
Published in:Journal of structural chemistry 2020-08, Vol.61 (8), p.1260-1266
Main Authors: Drebushchak, T. N., Mikhailovskaya, A. V., Drebushchak, V. A., Mikhailenko, M. A., Myz’, S. A., Shakhtshneider, T. P., Kuznetsova, S. A.
Format: Article
Language:English
Subjects:
Atomic
Atomic/Molecular Structure and Spectra
Chemistry
Chemistry and Materials Science
Crystal structure
Crystallinity
Crystals
Ethanol
Inorganic Chemistry
Molecular
Optical and Plasma Physics
Phase transitions
Physical Chemistry
Polymorphism
Recrystallization
Room temperature
Single crystals
Solid phases
Solid State Physics
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Summary:By recrystallization with different solvents as well as decomposition of betulin ethanol solvate at room temperature a new crystalline form of the biologically active compound betulin, namely hemihydrate of betulin, is obtained. By single crystal X-ray diffraction data the crystal structure of hemihydrate of betulin is determined. By powder X-ray thermodiffraction and differential scanning calorimetry it is found that when hemihydrate of betulin is heated to melting, Н 2 О molecules are removed and solid-phase transformations occur, which are related to the formation of an intermediate crystalline form and an orthorhombic modification of betulin.
ISSN:0022-4766
1573-8779
DOI:10.1134/S0022476620080119