The development of definition methodic of the nasal gel's “Phytorin-plus” active substances

Nasal gels on the modern pharmaceutical market are mainly represented by medicines of foreign production based on synthetic compounds. [...]the urgent task is to develop a new combined nasal gel based on natural raw materials for the treatment of viral rhinitis, followed by the study of its pharmaco...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2020-09, Vol.13 (9), p.4329-4333
Main Authors: Rukhmakova, O. A., Karpenko, I. A., Yarnykh, T. G.
Format: Article
Language:English
Subjects:
Chromatography
Drug dosages
Identification
Medicine
Membrane filters
Methods
Molecular weight
Oils & fats
Pharmacy
Pore size
Solvents
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Summary:Nasal gels on the modern pharmaceutical market are mainly represented by medicines of foreign production based on synthetic compounds. [...]the urgent task is to develop a new combined nasal gel based on natural raw materials for the treatment of viral rhinitis, followed by the study of its pharmacological, physical and chemical parameters6,7. The first stage in the development of methodic for the determination of GA was to determine the requirements for the selection of active component from the matrix consisting of a gel base (carbopol, triethanolamine, propylene glycol and ethanol) and essential oils of pine and eucalyptus. Chromatography is carried out on a liquid chromatograph with UV-detector under the following conditions: a column 0.10m x 4.6cm filled with silica gel for chromatography, with a particle size of 3.0 microns, with a pre-column (Nucleosil 1003C18100·4.6); speed of the mobile phase: 1.5ml/min; column temperature: 25°C; detection at wavelength: 254nm; injection volume: 20pl. S1 - average value of peak area of the test substance, calculated from the chromatogram of the test solution; S0 - average value of peak area of the test substance, calculated from the chromatogram of the comparison solution; m1 - weight of the sample of the medicine, g; m0 - weight of Pharmacopoeia Standard Sample of monoammonium glycyrrhizate, mg; P - content of the active substance in Pharmacopoeia Standard Sample of monoammonium glycyrrhizate, %; 823 - molecular weight of GA; 840 - molecular weight of monoammonium glycyrrhizate (without taking into account crystallization water).
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00765.9