Hydroxyethyl starch nanocapsules by multiple nanoemulsions for carrying and controlled release of lapachol

•A new approach in the production of polymeric nanocarriers for lipophilic drug.•Nanocapsules showed efficiency in encapsulation of lapachol.•Nanocarriers provided controlled lapachol release. In the present work, an alternative to synthesized nanocapsules in which the lipophilic core was a multiple...

Full description

Saved in:
Bibliographic Details
Published in:Materials letters 2020-09, Vol.274, p.127983, Article 127983
Main Authors: Pereira, Stéfano A., dos Santos, Sarah B.F., Rodrigues, Francisco A.M., Fechine, Lillian M.U.D., Vieira, Ícaro G.P., Denardin, Juliano C., Araneda, Fábian, Ribeiro, Maria Elenir N.P., Gramosa, Nilce V., Ricardo, Nágila M.P.S.
Format: Article
Language:English
Subjects:
Complex systems
Controlled release
Core-shell
Crosslinking
Drug delivery systems
Encapsulation
Lipophilicity
Materials science
Morphology
Multiple nanoemulsion
Nanocapsules
Nanoemulsions
Peppas model
Polyurethane resins
Shells
Synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•A new approach in the production of polymeric nanocarriers for lipophilic drug.•Nanocapsules showed efficiency in encapsulation of lapachol.•Nanocarriers provided controlled lapachol release. In the present work, an alternative to synthesized nanocapsules in which the lipophilic core was a multiple nanoemulsification forming a complex system constituted of various phases was studied. A primary emulsion (O/W) was poured into another lipophilic solvent, forming a multiple nanoemulsion (O/W/O) able to provide the encapsulation of lapachol, a lipophilic drug. The synthesized nanocapsules were well characterized and the results demonstrate a core-shell morphology, based on the polyurethane formation that exists in the cross-linked starch shell. Furthermore, these systems have moderate stability, with particle size measuring up to 274 nm. The nanocapsules containing lapachol encapsulated 73% of the drug initially added. This demonstrates success in the synthetic route adopted, evidenced by the efficiency of incorporation of the lapachol, in addition of providing a controlled release, reaching 51.4% in 24 h. This behavior shows that the polymeric shell influences the drug release profile and it is in accordance with the kinetic model proposed by Peppas.
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2020.127983