Optical, Fluorescence Lifetime, Sensing and DNA Binding Studies of a Laser Dye

Herein, the effects of media on the fluorescence characteristics (mainly quantum yield, lifetime and radiationless deactivation rate of the excited singlet state) of phenylene-1,4-ethylene-bis-(2-quinoxaline) laser dye, BQxVB have been reported. Also, the sensitivity of the dye to the proton has bee...

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Bibliographic Details
Published in:Journal of solution chemistry 2020-08, Vol.49 (7-8), p.945-970
Main Authors: El-Nahass, Marwa N., Fayed, Tarek A.
Format: Article
Language:English
Subjects:
Apoptosis
Bimetals
Binding
Chemistry
Chemistry and Materials Science
Condensed Matter Physics
Cyclodextrins
Deactivation
Deoxyribonucleic acid
DNA
Dyes
Fluorescence lifetime sensing devices
Geochemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Molecular docking
Nanoparticles
Oceanography
Physical Chemistry
Polarity
Proteins
Quinoxalines
Spectra
Sulfuric acid
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Summary:Herein, the effects of media on the fluorescence characteristics (mainly quantum yield, lifetime and radiationless deactivation rate of the excited singlet state) of phenylene-1,4-ethylene-bis-(2-quinoxaline) laser dye, BQxVB have been reported. Also, the sensitivity of the dye to the proton has been tested by studying the effect of changing the acidic properties of the medium. As with polarity, the acidity of solution provokes spectral changes. As the acidity of the medium increases (using H 2 SO 4 solutions), the pale yellow color of BQxVB changes to orange then violet and eventually to deep blue in concentrated acid solutions. The effect of metallic and bimetallic nanoparticles on the spectral behavior of BQxVB dye has been investigated. Additionally, the binding of the dye by β-cyclodextrin was investigated. The capped and binding of the dye with CT-DNA were visualized based on the spectral studies. Finally, a molecular docking analysis was carried out on five chosen proteins, which are largely responsible for the formation of CT-DNA, 4ASD-transferase, 3UW9 protein binding, 3DDC–hydrolase/apoptosis, 3L8-transferase/CT-DNA, and 4ICH-transcription. Based on the results, it has been clearly shown that BQxVB shows better docking with the 4ASD-transferase protein than the other selected proteins, with an estimated binding Gibbs energy of − 50.45 kJ·mol −1 , a total intermolecular energy of − 55.09 kJ·mol −1 , an inhibition constant of 1.48 nmol·dm −3 , and a binding efficiency of 80%.
ISSN:0095-9782
1572-8927
DOI:10.1007/s10953-020-01000-3