A multifuctional nanoplatform for drug targeted delivery based on radiation-engineered nanogels

Under a rational design, combining biologically active molecules, ligands to specific cell receptors and fluorescent, radioactive or paramagnetic labels into a single nano-object can bridge the unique properties of the individual components and improve conventional sensing, imaging and therapeutic e...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2020-04, Vol.169, p.108059, Article 108059
Main Authors: Sabatino, Maria Antonietta, Ditta, Lorena Anna, Conigliaro, Alice, Dispenza, Clelia
Format: Article
Language:English
Subjects:
Amines
Aqueous solutions
Biological properties
Chemical properties
Conjugation reactions
Drug delivery
Drug delivery systems
Electric bridges
Fluorescence
Functional groups
In vivo methods and tests
Ionising radiation synthesis
Ionizing radiation
Nanogels
Nanomedicine
Nanotechnology devices
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Summary:Under a rational design, combining biologically active molecules, ligands to specific cell receptors and fluorescent, radioactive or paramagnetic labels into a single nano-object can bridge the unique properties of the individual components and improve conventional sensing, imaging and therapeutic efficacies. The validation of these functional nano-objects requires careful testing both in terms of physico-chemical properties and biological behaviour in vitro and in vivo, prior to translation into the clinic. Ionising radiation of aqueous polymer solutions is a viable strategy to produce multifunctional nanogels from aqueous solutions of hydrophilic polymers. By proper selection of the irradiation conditions, polymer concentration and gaseous atmosphere, nanogels with the desired features in terms of dimensions, surface electric charge and chemical reactivity can be produced. In particular, radiation-engineered poly(N-vinyl pyrrolidone)-based nanogels bearing carboxyl groups and primary amines can be used as the main building block of promising theranostic nanodevices. The possibility of exploiting these functional groups to bind molecules of interest for their characterisation and biological evaluation is discussed. •Nanogels are fascinating delivery systems with great potential in the biomedical field.•Nanogels with various size and functional groups can be synthetized by e-beam irradiation from the same aqueous polymer.•Grafting of acrylic acid to PVP nanogels increases the number of functional groups that are available for conjugation reactions.•The covalent attachment of various (bio)molecules of interest on the same nanogel is demonstrated.•Nanogel-cell interactions are significantly affected by the conjugation reactions.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2018.11.013