Formulation and Evaluation of Etoricoxcib Emulgel for Topical Delivery

The aim of present study is to develop an emulgel formulation using Etoricoxcib an NSAID'S ,which effective in treatment of Osteoarthiritis, Rheumatoid Arthiritis , Acute Gouty Arthiritis, Ankylosing Spondylitis, etc.. geling agents like carbopol, HPMC with emulsifying agents span80 and tween80...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research 2020-07, Vol.12 (7), p.885-889
Main Authors: Usha, A, Mamatha, H S, Banupriya, M R
Format: Article
Language:English
Subjects:
Arthritis
Bioavailability
Drug delivery systems
Drug dosages
Olive oil
Personal appearance
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Summary:The aim of present study is to develop an emulgel formulation using Etoricoxcib an NSAID'S ,which effective in treatment of Osteoarthiritis, Rheumatoid Arthiritis , Acute Gouty Arthiritis, Ankylosing Spondylitis, etc.. geling agents like carbopol, HPMC with emulsifying agents span80 and tween80 and penetration enhancers like clove oil, olive oil, almond oil . Topical drug delivery system has several advantages such as ability to deliver drug more selectively to a specific site, avoidance of gastro intestinal incompatibility and metabolic degradation associated with oral administration more over topical deliveries provide increased bioavailability by avoiding first pass metabolism by liver and consistent delivery for extended period[4-5]. Etoricoxib ,HPMC K4M, Carbopol 940 , carbopol 934, were produced from Horizon Chemical Ltd. Span 80, twee80, propylene glycol methyl paraben, clove oil , almond oil, olive oil, were producrd from S.D. Fine Chem Ltd, Mumbai, India. formulation development The gel in formulation were prepared by dispersing polymer in purified water with constant stirring at a moderate speed then the Ph are adjusted to 6 to 6.5 using Tri Ethanol Amine (TEA). Both oil phase and aqueous phase were separately heated to 40° to 50°C then oily phase were added to aqueous phase with constant stirring until cooled to room temperature.
ISSN:0975-1459