Synthesis and Antimicrobial Activity of 5-(Het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones

A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized comp...

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Bibliographic Details
Published in:Russian journal of general chemistry 2020-07, Vol.90 (7), p.1222-1228
Main Authors: Gein, V. L., Rubtsova, D. D., Bobyleva, A. A., Ryabova, O. V., Novikova, V. V., Kasimova, N. N., Yankin, A. N.
Format: Article
Language:English
Subjects:
Aldehydes
Aromatic compounds
Carbonyls
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Fungicides
Synthesis
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Summary:A series of novel 5-(het)aryl-3-hydroxy-1-hydroxyethyl-4-(thienyl-2-carbonyl)-3-pyrrolin-2-ones was synthesized by reacting methyl thienyl-2-carbonylpyruvate with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activity of the synthesized compounds was studied.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220070087