Green Synthesis of Carbon Dots and Evaluation of Its Pharmacological Activities

In this study, an eco-friendly, cost-effective and fast microwave method of preparation of carbon dots was employed. The antimicrobial and cytotoxic activities of metal-based nanoparticles are well known, but the effects of carbon dot nanoparticles (C-dot NPs) are less explored. Stable C-dot NPs wer...

Full description

Saved in:
Bibliographic Details
Published in:BioNanoScience 2020-09, Vol.10 (3), p.731-744
Main Authors: Muktha, H., Sharath, R., Kottam, Nagaraju, Smrithi, S. P., Samrat, K., Ankitha, P.
Format: Article
Language:English
Subjects:
Anticancer properties
Antifungal activity
Bacillus subtilis
Biological activity
Biological and Medical Physics
Biomaterials
Biophysics
Biotechnology
Carbon
Carbon dots
Chemical compounds
Ciprofloxacin
Circuits and Systems
Cytotoxicity
E coli
Engineering
Escherichia coli
Fluconazole
Fluorescence
Fourier transforms
Fungicides
Fusarium oxysporum
Infrared spectra
Microorganisms
Nanoparticles
Nanotechnology
Organic wastes
Pharmacology
Plant extracts
Pseudomonas aeruginosa
Spectrum analysis
Staphylococcus aureus
Synthesis
Transmission electron microscopy
Tumor cell lines
Water melons
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, an eco-friendly, cost-effective and fast microwave method of preparation of carbon dots was employed. The antimicrobial and cytotoxic activities of metal-based nanoparticles are well known, but the effects of carbon dot nanoparticles (C-dot NPs) are less explored. Stable C-dot NPs were prepared from organic waste of pomegranate and watermelon peels and characterized by UV-visible spectrophotometer, fluorescent spectroscopy, Fourier transform infrared (FTIR) spectra, high-resolution transmission electron microscopy (HRTEM) and Raman’s spectroscopic techniques. The different biological applications of C-dots such as anti-microbial activity against Fusarium oxysporum , Staphylococcus aureus , Pseudomonas aeruginosa , Bacillus subtilis and Escherichia coli and the cytotoxic activity against MCF-7 and HepG2 cell lines were evaluated. The study revealed that the C-dots synthesized from pomegranate peel (P-C dots) have larger effect than those synthesized from the watermelon peel (W-C dots) on therapeutic properties. C-dots synthesized by pomegranate peel extract and watermelon peel extract have shown the anti-bacterial activity at the concentration of 80 μL (19.67 ± 0.37) on bacterial strains versus ciprofloxacin at 10 μg/mL (19.67 ± 0.40) which was used as control. P-C dots (61.00 ± 1.90) have shown significant antifungal activity when compared with the fluconazole (85 ± 0.90) and the W-C dots did not show any activity. Further, P-C dots and W-C dots were evaluated for cytotoxic activity. Both P-C dots and W-C dots have shown strong anti-cancer effects for cell lines; for MCF-7, P-C dots have shown significant effect when compared with W-C dots, whereas for HepG2 cell lines, both the C-dots are showing almost equal range of effects. This study reveals that the C-dots synthesized from organic wastes can be used as a therapeutic agent to treat human microbial infections.
ISSN:2191-1630
2191-1649
DOI:10.1007/s12668-020-00741-1