Mineralocorticoids, glucose homeostasis and type 2 diabetes mellitus: The Henan Rural Cohort study

We aimed to evaluate the associations of mineralocorticoids with type 2 diabetes mellitus (T2DM) and glucose homeostasis among rural Chinese adults. A total of 2713 participants were selected from the Henan Rural Cohort study. Serum mineralocorticoids were measured by liquid chromatography-tandem ma...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2020-05, Vol.34 (5), p.107558, Article 107558
Main Authors: Wei, Dandan, Liu, Xue, Jiang, Jingjing, Tu, Runqi, Qiao, Dou, Li, Ruiying, Wang, Yikang, Fan, Mengying, Yang, Xiu, Zhang, Jinyu, Hou, Jian, Huo, Wenqian, Yu, Songcheng, Li, Linlin, Wang, Chongjian, Mao, Zhenxing
Format: Article
Language:English
Subjects:
11-Deoxycorticosterone
Alcohol
Aldosterone
Blood pressure
Cohort analysis
Diabetes
Family medical history
Fasting plasma glucose
Glucose
Health risk assessment
Homeostasis
Hypertension
Insulin resistance
Kidney diseases
Marital status
Normal distribution
Pre-diabetes
Questionnaires
Salinity
Smoking
Software
Statistics
Type 2 diabetes mellitus
Urine
β cell function
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Summary:We aimed to evaluate the associations of mineralocorticoids with type 2 diabetes mellitus (T2DM) and glucose homeostasis among rural Chinese adults. A total of 2713 participants were selected from the Henan Rural Cohort study. Serum mineralocorticoids were measured by liquid chromatography-tandem mass spectrometry. Logistic regression and restricted cubic splines were employed to evaluate the associations of mineralocorticoids with pre-diabetes and T2DM. Linear regression was implemented to assess the associations of aldosterone and 11-deoxycorticosterone with different markers of glucose homeostasis by different diabetes status. Elevated aldosterone and 11-deoxycorticosterone were associated with an increased prevalence of pre-diabetes and T2DM (P 
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2020.107558