Methods for the Determination of Selective Androgen Receptor Modulators

The history of the appearance and development of selective androgen receptor modulators (SARMs) is described. The main classes of SARMs and various approaches to their determination are considered. The use of chromatography–mass spectrometry is shown to be promising for the reliable determination of...

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Bibliographic Details
Published in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2020-07, Vol.75 (7), p.835-850
Main Authors: Temerdashev, A. Z., Dmitrieva, E. V.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Androgens
Biological materials
Chemistry
Chemistry and Materials Science
Enzymes
Fearn, John Russell
Laboratory animals
Mass spectrometry
Methods
Modulators
Receptors
Reviews
Testosterone
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Summary:The history of the appearance and development of selective androgen receptor modulators (SARMs) is described. The main classes of SARMs and various approaches to their determination are considered. The use of chromatography–mass spectrometry is shown to be promising for the reliable determination of SARM traces in various samples. Well-known sample preparation and determination methods in biological materials are considered, and the metabolic pathways the best studied SARM (andarine) using cell cultures (in vitro) and laboratory animals and humans (in vivo) are compared.
ISSN:1061-9348
1608-3199
DOI:10.1134/S1061934820070187