New Amino-Acid Conjugates of Glycyrrhizic Acid

New conjugates of glycyrrhizic acid (GA) containing two amino-acid methyl esters (4-aminobutanoic, 6-aminohexanoic, 11-aminoundecanoic) were synthesized by the activated-ester method using N-hydroxysuccinimide (HOSu)-N,N′-dicyclohexylcarbodiimide (DCC). The conjugate of GA with 6-aminohexanoic acid...

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Bibliographic Details
Published in:Chemistry of natural compounds 2014-05, Vol.50 (2), p.317-320
Main Authors: Baltina, L. A., Jr, Stolyarova, O. V, Baltina, L. A, Kondratenko, R. M, Fedorova, V. A, Orshanskaya, Ya. A, Zarubaev, V. V
Format: Article
Language:English
Subjects:
6-aminohexanoic acid
Acids
Amino acids
Antiviral agents
antiviral properties
Conjugates
Esters
glycyrrhizin
Health aspects
Influenza A virus
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
Viruses
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Summary:New conjugates of glycyrrhizic acid (GA) containing two amino-acid methyl esters (4-aminobutanoic, 6-aminohexanoic, 11-aminoundecanoic) were synthesized by the activated-ester method using N-hydroxysuccinimide (HOSu)-N,N′-dicyclohexylcarbodiimide (DCC). The conjugate of GA with 6-aminohexanoic acid possessed pronounced antiviral activity against influenza virus AH1N1/pdm09 with EC₅₀ = 12.7 μM and SI = 32.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-014-0941-9