Long‐term results of the treatment of primary hyperhidrosis with oxybutynin: follow‐up of 1,658 cases

Background Hyperhidrosis (HH) is characterized by exaggerated sweating in a specific region due to hyperfunction of the sweat glands. In the late 2000s, we started treating patients with an anticholinergic, oxybutynin, that was not being used until then. Objectives To present, after 12 years of util...

Full description

Saved in:
Bibliographic Details
Published in:International journal of dermatology 2020-06, Vol.59 (6), p.709-715
Main Authors: Wolosker, Nelson, Kauffman, Paulo, de Campos, José R. M., Faustino, Carolina B., da Silva, Marcelo F. A., Teivelis, Marcelo P., Puech‐Leão, Pedro
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Adult
Anticholinergics
Axilla
Drug Administration Schedule
Face
Female
Follow-Up Studies
Hand
Humans
Hyperhidrosis
Hyperhidrosis - diagnosis
Hyperhidrosis - drug therapy
Hyperhidrosis - psychology
Male
Mandelic Acids - administration & dosage
Mandelic Acids - adverse effects
Middle Aged
Muscarinic Antagonists - administration & dosage
Muscarinic Antagonists - adverse effects
Patient Satisfaction - statistics & numerical data
Patients
Quality of Life
Retrospective Studies
Severity of Illness Index
Surveys and Questionnaires - statistics & numerical data
Sweat gland
Sweating
Time Factors
Treatment Outcome
Xerophthalmia - chemically induced
Xerophthalmia - diagnosis
Xerophthalmia - epidemiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Hyperhidrosis (HH) is characterized by exaggerated sweating in a specific region due to hyperfunction of the sweat glands. In the late 2000s, we started treating patients with an anticholinergic, oxybutynin, that was not being used until then. Objectives To present, after 12 years of utilizing this medication in our service, the substantial experience obtained with the use of oxybutynin as an initial treatment of HH in a large series of 1,658 patients. Methods We analyzed 1,658 patients treated with oxybutynin for HH from May 2006 to June 2018. The patients were divided into four groups according to the main site of HH: the plantar group, the axillary group, the facial group, and the palmar group. To measure the degree of satisfaction, a quality of life (QoL) questionnaire was used. Results Pre‐treatment QoL was poor or very poor in more than 94% of the cases, and the palmar group had the worst quality of life. After treatment, we observed an improvement in the quality of life in 77% of patients. More than 70% of the patients in all groups present moderate or optimal subjective clinical improvement in sweating after treatment. The group with the best result was the facial group. Intense dry mouth was reported in 24.9% of all patients in all groups. Conclusions This study included a large number of patients followed for a long period and demonstrated the good effectiveness of treatment with oxybutynin for hyperhidrosis in the main sites of sweating.
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.14872