Asymmetric Intramolecular Hydroalkoxylation of Unactivated Alkenes Catalyzed by Chiral N‐Triflyl Phosphoramide and TiCl4

Summary of main observation and conclusion By using a combination of a chiral N‐triflyl phosphoramide and TiCl4 as the catalyst, a new process for asymmetric intramolecular hydroalkoxylation of unactivated alkenes was developed, producing various chiral tetrahydrofuran derivatives in 51%—99% yields...

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Bibliographic Details
Published in:Chinese journal of chemistry 2020-06, Vol.38 (6), p.565-569
Main Authors: Zhao, Pengyuan, Cheng, Aolin, Wang, Xinxu, Ma, Jiguo, Zhao, Guoqing, Li, Yingkun, Zhang, Yi, Zhao, Baoguo
Format: Article
Language:English
Subjects:
Alkenes
Asymmetric catalysis
Asymmetric hydroalkoxylation
Asymmetry
Catalysts
Chiral super strong Brønsted acid
Chiral terahedrofuran
Cyclization
Tetrahydrofuran
Titanium chlorides
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Summary:Summary of main observation and conclusion By using a combination of a chiral N‐triflyl phosphoramide and TiCl4 as the catalyst, a new process for asymmetric intramolecular hydroalkoxylation of unactivated alkenes was developed, producing various chiral tetrahydrofuran derivatives in 51%—99% yields with 30%—71% ee's. A combination of N‐triflyl phosphoramide and TiCl4 challenges asymmetric hydroalkoxylation of unactivated alkenes.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201900544