Model development for prediction of the allergic response to the wheat proteins ω-5 gliadin and HMW-glutenin

As one of the eight foods that account for 90 % of food allergies, wheat must be excluded from the diet in patients suffering from wheat allergies. From studies of wheat-dependent exercise-induced anaphylaxis (WDEIA), which has been used as a model to develop hypoallergenic wheat, we now know that t...

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Bibliographic Details
Published in:Applied biological chemistry 2016-12, Vol.59 (6), p.827-831
Main Authors: Joo, Yong Hoon, Lee, Do Hun, Lee, Nam Taek, Chung, Namhyun
Format: Article
Language:English
Subjects:
Allergens
Allergies
Anaphylaxis
Applied Microbiology
Biological Techniques
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Cultivars
Food allergies
Gliadin
Gluten
Glutenin
Prediction models
Proteins
Regression analysis
Wheat
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Summary:As one of the eight foods that account for 90 % of food allergies, wheat must be excluded from the diet in patients suffering from wheat allergies. From studies of wheat-dependent exercise-induced anaphylaxis (WDEIA), which has been used as a model to develop hypoallergenic wheat, we now know that the gluten fraction of wheat protein, particularly ω-5 gliadin and high-molecular-weight (HMW)-glutenin, is responsible for the allergic response. However, studies of allergic responses with WDEIA have been performed with a single wheat cultivar. Thus, in an effort to provide more information for the development of hypoallergenic wheat, we compared various cultivars with different countries of origin and characteristics. For the first step, we compared the allergen contents (ω-5 gliadin and HMW-glutenin) in each cultivar and the allergic response caused by each cultivar. Domestic wheat cultivars had lower contents of ω-5 gliadin and HMW-glutenin than those of imported wheat cultivars. Additionally, some cultivars caused varying allergic responses due to their allergen components. From regression analysis of allergen contents and allergic responses in vivo, we suggest a prediction model to estimate the extent of allergic response based on the ω-5 gliadin and HMW-glutenin contents. Further studies are needed to analyze the biological interactions between allergens from various cultivars and allergic response factors.
ISSN:2468-0834
2468-0842
DOI:10.1007/s13765-016-0231-2