Enzyme‐Mediated Tumor Starvation and Phototherapy Enhance Mild‐Temperature Photothermal Therapy

Compared with conventional tumor photothermal therapy (PTT), mild‐temperature PTT brings less damage to normal tissues, but also tumor thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during mild‐temperature PTT might lead to toxic side effects...

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Bibliographic Details
Published in:Advanced functional materials 2020-04, Vol.30 (16), p.n/a
Main Authors: Gao, Ge, Jiang, Yao‐Wen, Guo, Yuxin, Jia, Hao‐Ran, Cheng, Xiaotong, Deng, Yu, Yu, Xin‐Wang, Zhu, Ya‐Xuan, Guo, Hao‐Yue, Sun, Wei, Liu, Xiaoyang, Zhao, Jing, Yang, Shihe, Yu, Zhi‐Wu, Raya, Fatima Maria Sierra, Liang, Gaolin, Wu, Fu‐Gen
Format: Article
Language:English
Subjects:
Adenosine triphosphate
Biocompatibility
cancer starvation therapy
Efficiency
Enzymes
enzyme‐enhanced phototherapy
Glucose oxidase
Heat shock proteins
Inhibitors
Light therapy
Liposomes
Materials science
mild‐temperature photothermal therapy
Side effects
thermo‐sensitive liposomes
Toxicity
Tumors
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Summary:Compared with conventional tumor photothermal therapy (PTT), mild‐temperature PTT brings less damage to normal tissues, but also tumor thermoresistance, introduced by the overexpressed heat shock protein (HSP). A high dose of HSP inhibitor during mild‐temperature PTT might lead to toxic side effects. Glucose oxidase (GOx) consumes glucose, leading to adenosine triphosphate supply restriction and consequent HSP inhibition. Therefore, a combinational use of an HSP inhibitor and GOx not only enhances mild‐temperature PTT but also minimizes the toxicity of the inhibitor. However, a GOx and HSP inhibitor‐encapsulating nanostructure, designed for enhancing its mild‐temperature tumor PTT efficiency, has not been reported. Thermosensitive GOx/indocyanine green/gambogic acid (GA) liposomes (GOIGLs) are reported to enhance the efficiency of mild‐temperature PTT of tumors via synergistic inhibition of tumor HSP by the released GA and GOx, together with another enzyme‐enhanced phototherapy effect. In vitro and in vivo results indicate that this strategy of tumor starvation and phototherapy significantly enhances mild‐temperature tumor PTT efficiency. This strategy could inspire people to design more delicate platforms combining mild‐temperature PTT with other therapeutic methods for more efficient cancer treatment. Thermosensitive liposomes made of DPPC and DSPE‐PEG2000 encapsulating GOx, ICG, and GA are presented. This system is used for synergistic starvation therapy, EEPT, and enhanced mild‐temperature PTT against tumors.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201909391