Cardiac Fibroblast Diversity

Cardiac fibrosis is a pathological condition that occurs after injury and during aging. Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying methods for curbing excess deposition of extracellular matrix is a better understanding of the cardiac fibroblast,...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of physiology 2020-02, Vol.82 (1), p.63-78
Main Author: Tallquist, Michelle D
Format: Article
Language:English
Subjects:
adventitia
Aging
Animals
Cell Lineage
Collagen
Drug development
Extracellular matrix
fibroblast
Fibroblasts
Fibroblasts - classification
Fibroblasts - physiology
Fibrosis
Heart
Heart - physiology
Heterogeneity
Humans
Identification methods
inflammation
Injury prevention
interstitium
myocardial infarction
Myocardium - pathology
myofibroblast
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiac fibrosis is a pathological condition that occurs after injury and during aging. Currently, there are limited means to effectively reduce or reverse fibrosis. Key to identifying methods for curbing excess deposition of extracellular matrix is a better understanding of the cardiac fibroblast, the cell responsible for collagen production. In recent years, the diversity and functions of these enigmatic cells have been gradually revealed. In this review, I outline current approaches for identifying and classifying cardiac fibroblasts. An emphasis is placed on new insights into the heterogeneity of these cells as determined by lineage tracing and single-cell sequencing in development, adult, and disease states. These recent advances in our understanding of the fibroblast provide a platform for future development of novel therapeutics to combat cardiac fibrosis.
ISSN:0066-4278
1545-1585
DOI:10.1146/annurev-physiol-021119-034527