Expression Analysis of lncRNAs in Refractory and Non-Refractory Epileptic Patients

Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the pathogenesis of neuropsychiatric disorders such as epilepsy. In the current study, we evaluated expression of eight lncRNAs in 80 epileptic patients (40 refractory and 40 non-refractory ones) and 40 normal individual using q...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular neuroscience 2020-05, Vol.70 (5), p.689-698
Main Authors: Mirzajani, Sara, Ghafouri-Fard, Soudeh, Habibabadi, Jafar Mehvari, Arsang-Jang, Shahram, Omrani, Mir Davood, Fesharaki, Seyed Sohrab Hashemi, Sayad, Arezou, Taheri, Mohammad
Format: Article
Language:English
Subjects:
Adult
Bayesian analysis
Biomarkers
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Cell Biology
Correlation analysis
Drug Resistant Epilepsy - genetics
Drug Resistant Epilepsy - metabolism
Drug Resistant Epilepsy - pathology
Epilepsy
Female
Females
Gender
Humans
Male
Mental disorders
Neurochemistry
Neurology
Neurosciences
Non-coding RNA
Pathogenesis
Peripheral blood
Proteomics
Regression analysis
Regression models
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Robustness
Statistical analysis
Subgroups
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the pathogenesis of neuropsychiatric disorders such as epilepsy. In the current study, we evaluated expression of eight lncRNAs in 80 epileptic patients (40 refractory and 40 non-refractory ones) and 40 normal individual using quantitative real-time PCR. Bayesian regression model showed significant higher expression of UCA1 in both refractory and non-refractory groups compared with controls (posterior beta of relative expression (RE) = 2.03, P value = 0.003, and posterior beta of RE = 4.05, P value 
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-019-01477-8