Mechanistic modeling of the SARS-CoV-2 disease map

Here we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map in which the detailed activity of the human signaling circuits related to the viral infection and the different antiviral responses, including immune and inflammatory activities, can be in...

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Bibliographic Details
Published in:bioRxiv 2020-04
Main Authors: Kinza Rian, Esteban-Medina, Marina, Hidalgo, Marta R, Cubuk, Cankut, Falco, Matias M, Loucera, Carlos, Gunyel, Devrim, Ostaszewski, Marek, Pena-Chilet, Maria, Dopazo, Joaquin
Format: Article
Language:English
Subjects:
Antiviral agents
COVID-19
Gene expression
Immunosuppressive agents
Inflammation
Overexpression
Severe acute respiratory syndrome coronavirus 2
Viral infections
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Summary:Here we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map in which the detailed activity of the human signaling circuits related to the viral infection and the different antiviral responses, including immune and inflammatory activities, can be inferred from gene expression experiments. Moreover, given to the mechanistic properties of the model, the effect of potential interventions, such as knock-downs, over-expression or drug effects (currently the system models the effect of more than 8000 DrugBank drugs) can be studied in specific conditions. This tool, with the holistic, systems biology approach to the understanding of the complexities of the viral infection process, will become an important asset in the search for efficient antiviral treatments. The tool is freely available at: http://hipathia.babelomics.org/covid19/. Competing Interest Statement The authors have declared no competing interest. Footnotes * http://hipathia.babelomics.org/covid19/
DOI:10.1101/2020.04.12.025577