Age‐specific reference ranges of serum anti‐müllerian hormone in healthy women and its application in diagnosis of polycystic ovary syndrome: a population study

Objective To establish the age‐specific centiles of serum anti‐müllerian hormone (AMH) levels in Chinese women, and to explore the use of multiples of median (MoM) AMH levels for the diagnosis of polycystic ovary syndrome (PCOS). Design An observational study. Setting University‐affiliated hospitals...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2020-05, Vol.127 (6), p.720-728
Main Authors: Li, HWR, He, Y‐L, Li, R, Wong, CYG, Sy, B, Lam, CW, Lam, KSL, Peng, H‐M, Mu, S, Schooling, M, Yeung, WSB, Ho, PC, Ng, EHY
Format: Article
Language:English
Subjects:
Adult
Age
Age‐specific reference range
Anti-Mullerian Hormone - blood
anti‐Müllerian hormone
Asian Continental Ancestry Group - statistics & numerical data
automated chemiluminescence assay
Biomarkers
Chinese women
Diagnosis
Female
Health Surveys
Humans
Infertility
Medical diagnosis
Menstruation
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Population studies
Reference Values
ROC Curve
Women's Health
Womens health
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Summary:Objective To establish the age‐specific centiles of serum anti‐müllerian hormone (AMH) levels in Chinese women, and to explore the use of multiples of median (MoM) AMH levels for the diagnosis of polycystic ovary syndrome (PCOS). Design An observational study. Setting University‐affiliated hospitals and community clinics. Population We included 3137 healthy women aged 20–44 years recruited prospectively or who had archived serum samples from previous research projects. Another validation cohort of 751 women with PCOS as well as ovulatory controls, which was a convenient sample of women attending for infertility or menstrual disorders, was also studied. Methods The serum samples were assayed for AMH by the automated Access AMH assay. Main outcome measures Age‐specific reference ranges were constructed on the primary cohort with the Lambda‐Mu‐Sigma method. The MoM AMH of each subject in the validation cohort was calculated. Results Centile curves of serum AMH level against age were established. MoM AMH was significantly higher in women with PCOS than in controls (P 
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.16147