Bee glue (propolis) improves reproductive organs, sperm quality and histological changes and antioxidant parameters of testis tissues in rats exposed to excess copper

This study was designed to determine the effects of propolis on the sperm quality, antioxidant and histological parameters in the testicular tissues of male Sprague Dawley rats exposed to excessive copper (Cu). In this aim, 24 rats were randomly divided into four groups as follows: the control, Cu,...

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Bibliographic Details
Published in:Andrologia 2020-05, Vol.52 (4), p.e13540-n/a
Main Authors: Seven, Ismail, Tatli Seven, Pinar, Gul Baykalir, Burcu, Parlak Ak, Tuba, Ozer Kaya, Seyma, Yaman, Mine
Format: Article
Language:English
Subjects:
Animals
antioxidant status
Antioxidants
Antioxidants - metabolism
Apoptosis
Caspase
Catalase
Cell proliferation
Copper
Copper - toxicity
Dietary supplements
Drug Evaluation, Preclinical
Edema
Epithelium
Glutathione
histological changes
Interstitial cells
Male
Malondialdehyde
Propolis
Propolis - pharmacology
Propolis - therapeutic use
Random Allocation
Rats, Sprague-Dawley
Reproductive organs
Rodents
Sperm
Spermatozoa - drug effects
Superoxide dismutase
Testes
Testis - drug effects
Testis - metabolism
Tubules
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Summary:This study was designed to determine the effects of propolis on the sperm quality, antioxidant and histological parameters in the testicular tissues of male Sprague Dawley rats exposed to excessive copper (Cu). In this aim, 24 rats were randomly divided into four groups as follows: the control, Cu, Propolis and Cu+Propolis. When compared to control group, Cu administration significantly decreased sperm motility and concentration, increased total abnormal sperm rate. It caused a significant induction the malondialdehyde (MDA), and reduction the superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) in testicular tissues. Also, it caused loss, disorganisation and vacuolation of the germinal epithelium, oedema of the interstitial tissues, proliferation of the interstitial cells, spilled immature spermatogenic cells in the lumen of some seminiferous tubules. A large number of active caspase‐3‐positive stained apoptotic cells and a significant decrease in Johnsen's testicular score were determined. However, significant ameliorations were observed in all sperm characteristics, MDA, SOD, CAT, GSH, seminiferous tubules, number of apoptotic cells and Johnsen's testicular score in Cu+Propolis group. Our results showed that oral supplementation of propolis had curative effect on the sperm quality, antioxidant and histological parameters in the testicular tissues of male Sprague Dawley rats exposed to Cu.
ISSN:0303-4569
1439-0272
DOI:10.1111/and.13540