Preparation, Characterization and Antioxidant Determination of Coumarin Substituted Heterocyclic Compound

The scavenging ability from different ethanolic solution ranging from (100-1000 ug/ml) of the new compound against stable DPPH radical (DPP-) was done and the results show that the coumarin derivative of this compound exhibited high antioxidant activates with scavenging activity reaching 80 % at con...

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Bibliographic Details
Published in:Asian Journal of Research in Chemistry 2020, Vol.13 (1), p.23-27
Main Authors: Abd-Almonuim, Afnan E., Mohammed, Shaimaa M., Al-Khalifa, Ihab I.
Format: Article
Language:English
Subjects:
Absorbance
Anticoagulants
Antioxidants
Ascorbic acid
Chemical synthesis
Coumarin
Dioxins
Free radicals
Heterocyclic compounds
Hydrocarbons
Hydrogen
Scavenging
Solvents
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Summary:The scavenging ability from different ethanolic solution ranging from (100-1000 ug/ml) of the new compound against stable DPPH radical (DPP-) was done and the results show that the coumarin derivative of this compound exhibited high antioxidant activates with scavenging activity reaching 80 % at concentration 1000 qg/mL , compared to vitamin c as standard antioxidant reaching 92% DPPH radical scavenging activity at the same concentration. Scavenging effect % = [(Ao-A)MJ x 100...Ao = Control absorbance; A = Tested absorbance (1) Results of this current study showed that in vitro antioxidant efficacy of the synthesized coumarin derivative had good antioxidant activity through hydrogen-donating action, measured utilizing 2,2diphenyl-1-picrylhydrazyl radicals as hydrogen acceptor, moreover, Fig.4 showed concentration -dependent association between the condensation from novel synthesized molecule as well the percentage from inhibition. On DPPH manner, the synthesized compounds possessing maximum scavenging activity about 80 % on condensation 1000pg/mL, compared to vitamin c as standard antioxidant reaching about 92% DPPH radical scavenging activity at the same concentration, moreover obtained results showed positive association between the scavenging impact which was increased for increasing condensation from check coumarin compound which was comparable to previous study by ( Ahmed A. Al-Amiery, et al 2015) [17] . [...]Fig. 5 showed linear regression equation for both coumarin derivative and vitamin C standard antioxidant based on showed outcomes the synthesized coumarin compound can be categories as mild free radical scavenger exhibits An important dose inhibition dependent on DPPH activity for 50% from inhibition (IC50) within condensation of 591.68pg/m (Figure 5a ) and IC50 value of Vit.C was 391.25pg/m (Figure 5b). logically, a higher DPPH radical-scavenging efficacy is linked for a lower IC50 value.
ISSN:0974-4169
0974-4150
DOI:10.5958/0974-4150.2020.00006.1