Assessment of the Biological Efficiency of 450 MeV/Nucleon Accelerated Carbon Ions in the U-70 Accelerator According to the Criterion of Mouse Survival

—The coefficients of the relative biological efficiency of a carbon ion beam with an energy of 450 MeV/nucleon upon the irradiation of mice at a dose of 6.5 Gy in different parts of the Bragg curve have been determined by the 30-day survival test, the dynamics of death, and the average life expectan...

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Published in:Biophysics (Oxford) 2019-11, Vol.64 (6), p.991-998
Main Authors: Zaichkina, S. I., Rozanova, O. M., Smirnova, E. N., Dyukina, A. R., Belyakova, T. A., Strelnikova, N. S., Sorokina, S. S., Pikalov, V. A.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Carbon
Complex Systems Biophysics
Death
Efficiency
Life span
Physics
Physics and Astronomy
Survival
X-rays
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Summary:—The coefficients of the relative biological efficiency of a carbon ion beam with an energy of 450 MeV/nucleon upon the irradiation of mice at a dose of 6.5 Gy in different parts of the Bragg curve have been determined by the 30-day survival test, the dynamics of death, and the average life expectancy of mice in comparison with exposure to X-ray radiation. The integral value ​​of the coefficients of the relative biological efficiency of carbon ions upon irradiation before the Bragg peak is 0.8, in the spread-out Bragg peak it is 1.5, and after the Bragg peak, it is 0.7. The value of the relative biological efficiency in the modified Bragg peak, as calculated by the ratio of doses that lead to the death of 50% of the animals, was 2.9. Changes of the width of the modified Bragg peak did not affect the death rate of the animals.
ISSN:0006-3509
1555-6654
DOI:10.1134/S000635091906023X