A mixture of fipronil and fungicides induces alterations on behavioral and oxidative stress parameters in zebrafish

Pesticide commercial mixtures, including the insecticide fipronil and the fungicides pyraclostrobin and methyl-thiophanate, have been used in concomitant pest control, facilitating agricultural management. Their widespread use can lead to soil and water contamination and potentially induce damages i...

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Bibliographic Details
Published in:Ecotoxicology (London) 2020-03, Vol.29 (2), p.140-147
Main Authors: Bevilaqua, Fernanda, Sachett, Adrieli, Chitolina, Rafael, Garbinato, Cristiane, Gasparetto, Henrique, Marcon, Matheus, Mocelin, Ricieri, Dallegrave, Eliane, Conterato, Greicy, Piato, Angelo, Siebel, Anna M.
Format: Article
Language:English
Subjects:
Agricultural management
Analysis
Animal behavior
Animals
Antioxidants
Behavior, Animal - physiology
Biological stress
Catalase
Chemical pest control
Contamination
Danio rerio
Earth and Environmental Science
Ecology
Ecosystem assessment
Ecotoxicology
Environment
Environmental effects
Environmental Management
Exposure
Fipronil
Freshwater fishes
Fungicides
Fungicides, Industrial
Insecticides
Oxidative stress
Oxidative Stress - physiology
Parameters
Pest control
Pesticides
Pyrazoles - toxicity
Sediment pollution
Soil
Soil contamination
Soil pollution
Soil water
Superoxide dismutase
Thiophanate
Toxicity
Toxicology
Water Pollutants, Chemical - toxicity
Water pollution
Zebrafish
Zebrafish - physiology
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Summary:Pesticide commercial mixtures, including the insecticide fipronil and the fungicides pyraclostrobin and methyl-thiophanate, have been used in concomitant pest control, facilitating agricultural management. Their widespread use can lead to soil and water contamination and potentially induce damages in the ecosystem, producing toxic effects in non-target organisms. Despite their toxicological potential, their effects on behavioral and biochemical parameters are not well understood. Here we investigated the effects of the mixture of fipronil and fungicides (MFF) pyraclostrobin and methyl- thiophanate on behavioral and biochemical parameters of oxidative stress in adult zebrafish. Animals exposed to the highest MFF tested concentration showed a decrease in the total distance traveled and in the number of crossings in the different zones of the tank. Furthermore, animals exposed to highest MFF tested concentration spent more time in water surface. In addition, our data showed that the exposure to this preparation promoted a decrease in non-protein thiol content as well as in catalase activity. Finally, pesticide exposure induced an increase in the superoxide dismutase/catalase ratio. Our results indicate that alterations in behavioral and oxidative parameters are involved in MFF toxicity in zebrafish. The antioxidant mechanisms analyzed were altered in concentrations that did not affect zebrafish behavior. Therefore, the assessment of oxidative stress parameters in zebrafish brains could be very useful to detect the early effects of environmental exposure to the MFF.
ISSN:0963-9292
1573-3017
DOI:10.1007/s10646-019-02146-7