0139 SUVN-G3031, A Potent and Selective Histamine H3 Receptor Inverse Agonist - Phase-2 Investigational New Drug for the Treatment of Narcolepsy - Differentiating Factors with Competitor Clinical Candidates

Introduction SUVN-G3031 is one of the potent H3 receptor (H3R) inverse agonist in the clinical development for the treatment of narcolepsy with or without cataplexy. Phase-1 evaluation for safety, tolerability and pharmacokinetics, and long term safety studies in animals has been successfully comple...

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Bibliographic Details
Published in:Sleep (New York, N.Y.) N.Y.), 2019-04, Vol.42 (Supplement_1), p.A57-A57
Main Authors: Nirogi, Ramakrishna, Bhyrapuneni, Gopinadh, Abraham, Renny, Subramanian, Ramkumar, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Badange, Rajesh, Shinde, Anil
Format: Article
Language:English
Subjects:
Competition
Sleep disorders
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Summary:Introduction SUVN-G3031 is one of the potent H3 receptor (H3R) inverse agonist in the clinical development for the treatment of narcolepsy with or without cataplexy. Phase-1 evaluation for safety, tolerability and pharmacokinetics, and long term safety studies in animals has been successfully completed. Methods Extensive nonclinical profiling was carried out for SUVN-G3031 and H3R receptor antagonists/inverse agonists that are in active clinical development for the treatment of sleep related disorders. The nonclinical parameters like binding affinity at human and rat H3R, selectivity profiling, in-vivo and in-vitro ADME features, nonclinical efficacy, neurochemistry and safety were evaluated. Results SUVN-G3031 has no inter-species variation in binding affinity at H3R with >100 fold selectivity. Unlike competitor compound, SUVN-G3031 has no binding affinity at sigma 1 and 2 receptor up to the highest tested concentration of 10 µM. SUVN-G3031 has no inhibition and induction liability against major CYP isoforms and is neither an inhibitor nor a substrate of major uptake transporters. SUVN-G3031 has moderate plasma protein binding. SUVN-G3031 has superior oral pharmacokinetic and brain penetration properties in rat than the competitor compound. EEG study indicated wake promoting profile of SUVN-G3031 is superior than compounds of this class active in clinical development. SUVN-G3031 showed negligible affinity towards hERG channel (IC50 > 10 µM) and had no effects on any ECG parameters in dog telemetry study. SUVN-G3031 showed no convulsions or signs of other CNS safety. Unlike competitor compound, SUVN-G3031 has no adverse effects on fertility and embryo-fetal development up to highest tested doses. In long term toxicity studies, NOAEL exposures are several folds higher than competitor candidate. Conclusion Nonclinical studies demonstrated superior differentiating features of SUVN-G3031 over compounds of this class that are currently in active clinical development for the treatment of sleep related disorders. Phase-2 POC study for the treatment of narcolepsy is being planned in USA. Support (If Any) None
ISSN:0161-8105
1550-9109
DOI:10.1093/sleep/zsz067.138