The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer

Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end,...

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Bibliographic Details
Published in:Chemical Society reviews 2020-02, Vol.49 (4), p.141-156
Main Authors: Lo, Pui-Chi, Rodríguez-Morgade, M. Salomé, Pandey, Ravindra K, Ng, Dennis K. P, Torres, Tomás, Dumoulin, Fabienne
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
Biocompatible Materials - therapeutic use
Cancer
Humans
Indoles - chemistry
Indoles - therapeutic use
Light
Metal Nanoparticles - chemistry
Metal Nanoparticles - therapeutic use
Neoplasms - drug therapy
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - therapeutic use
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - metabolism
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Summary:Phthalocyanines exhibit superior photoproperties that make them a surely attractive class of photosensitisers for photodynamic therapy of cancer. Several derivatives are at various phases of clinical trials, and efforts have been put continuously to improve their photodynamic efficacy. To this end, various strategies have been applied to develop advanced phthalocyanines with optimised photoproperties, dual therapeutic actions, tumour-targeting properties and/or specific activation at tumour sites. The advantageous properties and potential of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer are highlighted in this tutorial review. Due to their photoproperties and easy chemical functionalisations, phthalocyanines are amongst the most promising advanced photosensitisers for photodynamic therapy of cancer.
ISSN:0306-0012
1460-4744
DOI:10.1039/c9cs00129h