PIXE analysis of blood serum of breast cancer patients undergoing successive chemotherapy

Particle induced X-ray emission technique was used to obtain the serum elemental profile of healthy subjects and breast cancer patients (BCPs) undergoing chemotherapy. Concentrations of elements K, Ca, Ti, V, Cr, Mn, Fe, Co, Cu, Zn, Se, Br, Rb, and Sr were determined. The increased levels of Ca, Cr,...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2020-03, Vol.323 (3), p.1307-1316
Main Authors: Naidu, B. Gowri, Srikanth, S., Raju, G. J. Naga, Sarita, P.
Format: Article
Language:English
Subjects:
Analysis
Biological products
Breast cancer
Calcium
Cancer
Cancer patients
Carboplatin
Care and treatment
Chemistry
Chemistry and Materials Science
Chemotherapy
Chromium
Copper
Diagnostic Radiology
Emission
Hadrons
Heavy Ions
Inorganic Chemistry
Iron
Manganese
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
Selenium
Trace elements
Zinc
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Summary:Particle induced X-ray emission technique was used to obtain the serum elemental profile of healthy subjects and breast cancer patients (BCPs) undergoing chemotherapy. Concentrations of elements K, Ca, Ti, V, Cr, Mn, Fe, Co, Cu, Zn, Se, Br, Rb, and Sr were determined. The increased levels of Ca, Cr, Fe and Cu and diminished levels of Ti, Zn, and Se observed in BCPs prior to therapy, were restored to near normal levels after the fifth cycle of chemotherapy. This work elicits a unique possibility of identifying novel trace element based anti-tumour drugs for breast cancer.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-019-06988-7