12(S)-HETE Enhancement of Prostate Tumor Cell Invasion: Selective Role of PKC

The effect of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the motility and invasion of low-metastatic rate prostate AT2.1 tumor cells and the effect of 12(S)-HETE activation of specific protein kinase C (PKC) isoforms in these processes were examined in rats. Results indicate that 12(S)-HETE...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1994-08, Vol.86 (15), p.1145-1151
Main Authors: Liu, B., Maher, R. J., Hannun, Y. A., Porter, A. T., Honn, K. V.
Format: Article
Language:English
Subjects:
Biochemistry
Prostate cancer
Rodents
Tumors
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Summary:The effect of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the motility and invasion of low-metastatic rate prostate AT2.1 tumor cells and the effect of 12(S)-HETE activation of specific protein kinase C (PKC) isoforms in these processes were examined in rats. Results indicate that 12(S)-HETE augments the invasiveness of AT2.1 cells via selective activation of PKCalpha.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/86.15.1145