In situ synthesized hydro-lipophilic nano and micro fibrous bacterial cellulose: polystyrene composites for tissue scaffolds

3D networks of fibrous materials are preferred for cell growth and proliferation as they mimic the extracellular matrix. Moreover, materials with the multi-dimensional fibers, that is, a combination of nano- and microfibers, are preferred as they would benefit from the high surface area offered by n...

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Bibliographic Details
Published in:Journal of materials science 2020-04, Vol.55 (12), p.5247-5256
Main Authors: Anju, P. V., Khandelwal, Mudrika, Subahan, Mabu P., Kalle, Arunasree M., Mathaparthi, Srinadh
Format: Article
Language:English
Subjects:
Bacteria
Cell growth
Cellulose
Cellulose fibers
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Crystallography and Scattering Methods
Fiber reinforced plastics
Hydrophilicity
Laminates
Materials for Life Sciences
Materials Science
Microfibers
Morphology
Multilayers
Nanofibers
Nutrition
Polymer matrix composites
Polymer Sciences
Polystyrene
Polystyrene resins
Pore size
Porosity
Solid Mechanics
Structural integrity
Surface area
Textile fabrics
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Summary:3D networks of fibrous materials are preferred for cell growth and proliferation as they mimic the extracellular matrix. Moreover, materials with the multi-dimensional fibers, that is, a combination of nano- and microfibers, are preferred as they would benefit from the high surface area offered by nanofibers and structural integrity imparted by the microfibers. This paper presents a unique and facile way of making such fiber-on-fiber composites from bacterial cellulose nanofibers and polystyrene (PS) microfibers. These composites are unique as the PS microfibers are lipophilic, while the cellulose nanofibers are hydrophilic. This not only enables cell attachment but also ensures nutrition supply. Two types of composites were obtained in this work—interpenetrated and layered—by in situ growth of bacterial cellulose into compressed and uncompressed nonwoven PS fabrics, respectively. The layered composite showed two times the cell growth exhibited by the control, while the interpenetrated composite offered a fourfold cell growth, after 24 h. Later (at 48 h), the interpenetrated composites show a decline in cell growth, while the layered composite showed an increase. The role of hydrophilic cellulose fibers in nutrition supply, lipophilic PS in cell attachment, optimal pore size in cell trapping and surface area in enhanced growth is discussed, in addition to the role of the composite morphology (layered or interpenetrated) in cell growth.
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-020-04344-9