Preparation and physicochemical characterization of drug loaded in castor oil-based polyurethane

Castor oil is an environmentally friendly alternative to hydrocarbon-based feedstocks for the synthesis of polyurethanes due to its major constituent, ricinoleic acid. This work aimed to obtain and characterize castor oil-based polyurethane (coPU) systems containing domperidone and verapamil hydroch...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2020-02, Vol.139 (3), p.1949-1957
Main Authors: Fortes, Amanda C., Bezzon, Vinicius D. N., de Araújo, Gabriel L. B., Santos, Carlos O. P., Ferraz, Humberto G.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Calcium channel blockers
Calorimetry
Castor oil
Chemistry
Chemistry and Materials Science
Diffraction
Drug delivery systems
Evaporation
Fourier transforms
Functional groups
Hydrogen
Hydrogen bonding
Hydrogen bonds
Imidazole
Infrared spectroscopy
Inorganic Chemistry
Isocyanates
Measurement Science and Instrumentation
Organic chemistry
Physical Chemistry
Polymer Sciences
Polymers
Polyurethane resins
Polyurethanes
Prepolymers
Ricinoleic acid
Solvents
Thermogravimetry
X ray powder diffraction
X-rays
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Castor oil is an environmentally friendly alternative to hydrocarbon-based feedstocks for the synthesis of polyurethanes due to its major constituent, ricinoleic acid. This work aimed to obtain and characterize castor oil-based polyurethane (coPU) systems containing domperidone and verapamil hydrochloride, separately, as model drugs. The drug-loaded coPU systems were obtained by solvent evaporation method and were characterized by differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. Additionally, dissolution studies and scanning electron microscopy were performed. Verapamil hydrochloride was successfully incorporated in coPU, once it interacted through hydrogen bonds, and this system showed as a potential candidate for sustained drug release. Domperidone precipitated during solvent evaporation, resulting in a drug suspension into the polymer matrix. However, around 20% of domperidone interacted chemically with the polymer by the reaction of the active hydrogen of domperidone imidazole groups with the terminal isocyanate of the prepolymer. Finally, the drug release profile is guided by the drug–polymer physicochemical interaction, which will depend on the drug and polymer functional groups that are stereochemically available.
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-019-08607-9