Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing

Thermomechanical engineering of pharmaceutical salts in the solid state using continuous extrusion processing (ssTME) is a new novel manufacturing approach. In the present work, we introduce a paradigm for the synthesis of ketoconazole – oxalic acid and ciprofloxacin – maleic acid salts by imparting...

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Bibliographic Details
Published in:Green chemistry : an international journal and green chemistry resource : GC 2020, Vol.22 (2), p.540-549
Main Authors: Mithu, Md Sadeque Hossain, Ross, Steven A., Alexander, Bruce D., Douroumis, Dennis
Format: Article
Language:English
Subjects:
Ciprofloxacin
Continuous extrusion
Engineering
Green chemistry
Information processing
Ketoconazole
Maleic acid
Oxalic acid
Pharmaceuticals
Salts
Shear rate
Solid state
Solvents
Synthesis
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Summary:Thermomechanical engineering of pharmaceutical salts in the solid state using continuous extrusion processing (ssTME) is a new novel manufacturing approach. In the present work, we introduce a paradigm for the synthesis of ketoconazole – oxalic acid and ciprofloxacin – maleic acid salts by imparting temperature, shear rate and stress in comparison to liquid assisted grinding (LAG) approach. We demonstrated that thermomechanical synthesis is advantageous by producing high quality and pure, solvent-free pharmaceutical salts by tailoring extrusion processing variables.
ISSN:1463-9262
1463-9270
DOI:10.1039/C9GC03528A