Decreased Protein Z Concentrations Complicating the Hypercoagulable State of Behqet's Disease

Protein Z is a vitamin-K-dependent plasma protein that serves as a cofactor for the inhibition of factor Xa. Although the precise physiologic function of protein Z is still unknown, abnornal plasma protein Z concentrations have been associated with a number of thrombotic disease states. There is the...

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Published in:Clinical and applied thrombosis/hemostasis 2003-07, Vol.9 (3), p.259-263
Main Authors: Öztüirk, M. Akif, Özbalkan, Zeynep, Onat, A. Mesut, Ertenli, Ihsan, Kiraz, Sedat, Aytemir, Kudret, Ureten, Kemal, Abali, Gulcan, Çalgüineri, Meral, Kirazli, Şerafettin, Haznedaroglu, Ibrahim C.
Format: Article
Language:English
Subjects:
Plasma
Proteins
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Summary:Protein Z is a vitamin-K-dependent plasma protein that serves as a cofactor for the inhibition of factor Xa. Although the precise physiologic function of protein Z is still unknown, abnornal plasma protein Z concentrations have been associated with a number of thrombotic disease states. There is the evidence of universal activation of the hemostatic system in Behqet's disease (BD), which represents a hypercoagulable/prothrombotic state. Circulating protein Z levels in patients with BD were evaluated. Plasma protein Z concentrations were assayed in 24 patients with BD (male/female: 13/11, mean age 35.4 years) and in 24 healthy controls (males/females: 14/10, mean age 59.8 years). The disease duration was 10.6 years (range, 1-30 years). None of the subjects in either group had received anticoagulants within 3 weeks before the study, and none of them had liver dysfunction. Patients complicated with vascular disease were also excluded from the study. Mean plasma concentrations of protein Z were 141 ng/mL (range, 56.8-257) in healthy controls and 107.8 ng/mL (range, 21.2-202) in BD patients (p
ISSN:1076-0296
1938-2723
DOI:10.1177/107602960300900312