Laboratory Monitoring of Platelet P2Y12 Receptor Inhibitors and Reversal of Antiplatelet Agents: An ACLPS Critical Review

Objectives: To review the use of laboratory tests for antiplatelet agents to determine escalation of antiplatelet therapy and for emergent reversal of P2Y12 inhibitors. Methods: A case scenario and review of cardiovascular and neurointerventional literature are described. Results: In cardiovascular...

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Bibliographic Details
Published in:American journal of clinical pathology 2019-07, Vol.152 (1), p.1-6
Main Authors: Senzel, Lisa, Ahmed, Tahmeena, Spitzer, Eric D
Format: Article
Language:English
Subjects:
Aggregation
Blood platelets
Cardiovascular diseases
Cell receptors
Clinical trials
Clopidogrel
Dose-response relationship (Biochemistry)
Health aspects
Laboratories
Pharmacology, Experimental
Platelets
Vasodilator-stimulated phosphoprotein
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Summary:Objectives: To review the use of laboratory tests for antiplatelet agents to determine escalation of antiplatelet therapy and for emergent reversal of P2Y12 inhibitors. Methods: A case scenario and review of cardiovascular and neurointerventional literature are described. Results: In cardiovascular disease patients, large randomized trials failed to demonstrate superiority of tailored antiplatelet regimens using the Verify Now P2Y12 assay, where earlier studies had shown promise. Platelet transfusions restored platelet function measured by vasodilator-stimulated phosphoprotein, light transmission aggregometry, or thromboelastography but not VerifyNow P2Y12, with the most restoration for clopidogrel and the least for ticagrelor. Conclusions: Current evidence does not support changing antiplatelet therapy based on the results of platelet function monitoring tests. For emergent reversal of P2Y12 inhibitors, test method can affect platelet dosing recommendations, as different methods may give different results. Key Words: Platelet; Clopidogrel; Polnt-of-care
ISSN:0002-9173
1943-7722
DOI:10.1093/AJCP/AQY151