MMR deficiency may lead to a high immunogenicity and then an improvement in anti-PD-1 efficacy for metastatic colorectal cancer

[...]the cell produces many mutated proteins that can be recognized as neo-epitopes by the immune system. [...]a relationship exists between the amount of somatic mutations and the clinical response to the treatment (10). [...]this trial has shown enthusiastic results that will permit more research...

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Bibliographic Details
Published in:Immunotherapy 2015-11, Vol.7 (11), p.1133-1134
Main Authors: Aguiar, Pedro Nazareth, Tadokoro, Hakaru, Forones, Nora Manoukian, de Mello, Ramon Andrade
Format: Article
Language:English
Subjects:
Cancer therapies
Colorectal cancer
Colorectal carcinoma
Epitopes
Gastric cancer
Hypotheses
Immune system
Immunogenicity
Immunotherapy
Lung cancer
Medical prognosis
Metastases
Metastasis
MMR
Monoclonal antibodies
Mutation
pembrolizumab
Proteins
Response rates
Targeted cancer therapy
Tumors
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Summary:[...]the cell produces many mutated proteins that can be recognized as neo-epitopes by the immune system. [...]a relationship exists between the amount of somatic mutations and the clinical response to the treatment (10). [...]this trial has shown enthusiastic results that will permit more research in order to approve a new agent for metastatic colorectal cancer.
ISSN:1750-743X
1750-7448
DOI:10.2217/imt.15.84