Site and mechanism of action of dynorphin A-(1-13) and N-methyl-D-aspartate on ACTH release in fetal sheep

Dynorphin A (Dyn A) stimulates the release of ACTH in fetal sheep, a response that involves N-methyl-D-aspartate (NMDA) receptors but not the secretogogues corticotropin-releasing hormone or arginine vasopressin. Furthermore, the release of ACTH by Dyn A-(1-13) and NMDA was abolished after pretreatm...

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Bibliographic Details
Published in:American journal of physiology: endocrinology and metabolism 2002-06, Vol.45 (6), p.E1301-E1307
Main Authors: NARDO, Laura, YI SOONG, DUNLI WU, YOUNG, I. Ross, WALKER, David, SZETO, Hazel H
Format: Article
Language:English
Subjects:
Amino acids
Biological and medical sciences
Case studies
Embryology: invertebrates and vertebrates. Teratology
Fundamental and applied biological sciences. Psychology
Hormones
Organogenesis. Fetal development
Organogenesis. Physiological fonctions
Sheep
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Summary:Dynorphin A (Dyn A) stimulates the release of ACTH in fetal sheep, a response that involves N-methyl-D-aspartate (NMDA) receptors but not the secretogogues corticotropin-releasing hormone or arginine vasopressin. Furthermore, the release of ACTH by Dyn A-(1-13) and NMDA was abolished after pretreatment with indomethacin, suggesting that they might cause the release of a prostanoid, possibly from the placenta, that subsequently acts at the hypothealamus or serves as a permissive factor in the action of Dyn A-(1-13) and NMDA at the hypothalamus.
ISSN:0193-1849
1522-1555