Altered corticosteroid metabolism differentially affects pituitary corticotropin response

To evaluate the effects of altered corticosteroid metabolism on the hypothalamic-pituitary-adrenal axis, we examined rats treated with glycyrrhizic acid (G rats) or rifampicin (R rats) for 7 days. The half-life of exogenously administered hydrocortisone as a substitute for corticosterone was longer...

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Published in:American journal of physiology: endocrinology and metabolism 2002-02, Vol.45 (2), p.E466-E473
Main Authors: HANAFUSA, Junko, MUNE, Tomoatsu, TANAHASHI, Tetsuya, ISOMURA, Yukinori, SUWA, Tetsuya, ISAJI, Mako, DAIDO, Hisashi, MORITA, Hiroyuki, MURAYAMA, Masanori, YASUDA, Keigo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Enzymes
Hormones
Metabolism
Pituitary gland
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Summary:To evaluate the effects of altered corticosteroid metabolism on the hypothalamic-pituitary-adrenal axis, we examined rats treated with glycyrrhizic acid (G rats) or rifampicin (R rats) for 7 days. The half-life of exogenously administered hydrocortisone as a substitute for corticosterone was longer in G rats and shorter in R rats, with no differences in basal plasma levels of ACTH or corticosterone.
ISSN:0193-1849
1522-1555