Biodistribution and toxicity of orally administered poly (lactic-co-glycolic) acid nanoparticles to F344 rats for 21 days

Quantify the biodistribution and assess the toxicity of PLGA (poly-lactic-co-glycolic acid) and surface-modified PLGA chitosan (PLGA/Chi) nanoparticles (NPs) orally administered for 7, 14 and 21 days to F344 rats. Fluorescent NPs were tracked in F344 rat tissues, and toxicity was evaluated by alkali...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2016-07, Vol.11 (13), p.1653-1669
Main Authors: Navarro, Sara M, Morgan, Timothy W, Astete, Carlos E, Stout, Rhett W, Coulon, Diana, Mottram, Peter, Sabliov, Cristina M
Format: Article
Language:English
Subjects:
Acids
Administration, Oral
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Animals
biodistribution
Biomedical materials
Chemistry
Chitosan - chemistry
Drug Carriers
Drug delivery systems
Drug dosages
Humans
Lactic Acid - chemistry
Lactic Acid - pharmacokinetics
Lactic Acid - toxicity
Liver
Nanoparticles
Nanoparticles - chemistry
Nanoparticles - toxicity
Particle Size
Phosphatase
Polyglycolic Acid - chemistry
Polyglycolic Acid - pharmacokinetics
Polyglycolic Acid - toxicity
Polyvinyl alcohol
Rats, Inbred F344
Rodents
Spleen
Surface Properties
Surfactants
Tissue Distribution
toxicity
Toxicity Tests, Subacute
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Summary:Quantify the biodistribution and assess the toxicity of PLGA (poly-lactic-co-glycolic acid) and surface-modified PLGA chitosan (PLGA/Chi) nanoparticles (NPs) orally administered for 7, 14 and 21 days to F344 rats. Fluorescent NPs were tracked in F344 rat tissues, and toxicity was evaluated by alkaline phosphatase and alanine transaminase levels, and by histologic examination of tissue samples. Biodistribution of PLGA and PLGA/Chi were similar, with highest amounts found in the intestine and liver. Alkaline phosphatase increased significantly in treated rats. Mild histological differences were detected in the intestine and liver. PLGA and PLGA/Chi NPs behaved similarly presenting minimal toxicity in the liver and intestine, but not in kidney, lung and brain.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2016-0022