Effect of the TNF-308 G/A Polymorphism on the Changes Produced by Atorvastatin in Bone Mineral Density in Patients with Acute Coronary Syndrome

Aims: To evaluate the effect of atorvastatin on bone mass and markers of bone remodeling in patients with acute coronary syndrome depending on the tumor necrosis factor-α (TNFα)-308 G/A polymorphism. Methods: Sixty-two patients with acute coronary syndrome (35 males and 27 females), average age 60 ±...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 2008-11, Vol.53 (2), p.117-121
Main Authors: Perez-Castrillon, Jose Luis, Vega, Gemma, Abad, Laura, Sanz-Cantalapiedra, Alberto, Gonzalez Sagredo, Manuel, Luis, Daniel de, Duenas-Laita, Antonio
Format: Article
Language:English
Subjects:
acute coronary syndrome
animal models
anticarcinogenic activity
Ascorbigen
atorvastatin
biomarkers
blood lipids
Bone density
Brassica
Cardiovascular disease
cardiovascular diseases
cultured cells
disease prevalence
Drug therapy
enzyme activity
genetic polymorphism
Genotype & phenotype
glucosinolates
hepatocytes
liver
messenger RNA
metabolic detoxification
NADP (coenzyme)
oxidoreductases
patients
Polymorphism
quinones
rats
Statins
tumor necrosis factor-alpha
xenobiotics
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Summary:Aims: To evaluate the effect of atorvastatin on bone mass and markers of bone remodeling in patients with acute coronary syndrome depending on the tumor necrosis factor-α (TNFα)-308 G/A polymorphism. Methods: Sixty-two patients with acute coronary syndrome (35 males and 27 females), average age 60 ± 10 years, were included. Patients were given low (10-20 mg) and high doses (40-80 mg) atorvastatin according to their baseline levels of cholesterol and triglycerides and their index of vascular risk. Patients were studied during hospital admission (baseline) and at 12 months of follow-up. Cholesterol, triglycerides, total calcium, phosphorus, magnesium, osteocalcin and urinary deoxypyridinoline were determined in all patients at baseline and at 12 months of follow-up. Densitometric studies were conducted in the lumbar spine (L2-L4), femoral neck and trochanter using an X-ray densitometer. The TNF-308 G/A polymorphism was determined by the polymerase chain reaction.Results:Forty-five patients were homozygous for G/G (72.5%) and 17 were heterozygous for G/A (27.5%). The prevalence of osteoporosis (T score
ISSN:0250-6807
1421-9697