A novel one-pot synthesis method of 3,4,5-triaryl-substituted 1,2,4-triazoles

A novel method for the preparation of 3,4,5-triaryl-substituted 1,2,4-triazoles by the reaction of hydrazides with secondary amides in polyphosphoric ester has been developed. The new method is characterized by mild conditions and ease of synthesis, including the stages of isolation and purification...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2019-09, Vol.55 (9), p.834-838
Main Authors: Yakuschenko, Igor K., Pozdeeva, Natal’ya N., Gadomsky, Svyatoslav Ya
Format: Article
Language:English
Subjects:
Amides
Antifungal agents
Chemistry
Chemistry and Materials Science
Hydrazides
Hydroxyl groups
Organic Chemistry
Pharmacy
Substitutes
Synthesis
Triazoles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel method for the preparation of 3,4,5-triaryl-substituted 1,2,4-triazoles by the reaction of hydrazides with secondary amides in polyphosphoric ester has been developed. The new method is characterized by mild conditions and ease of synthesis, including the stages of isolation and purification of the product. Additionally, product structures were confirmed by counter synthesis. It was shown that the proposed method is suitable for producing 1,2,4-triazoles with phenolic substituents without the stages of the protection and deprotection of the hydroxyl group. Using the new method, five 3,4,5-substituted 1,2,4-triazoles were obtained for the first time.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-019-02545-y