Design, development and characterization of ketorolac tromethamine polymeric nanosuspension

At present, various ophthalmic formulations show low bioavailability. The rationale of present work was to design and develop stable ketorolac tromethamine nanosuspension with sustained effect and greater permeability for ocular drug delivery and increased ocular residence.   Formulations were desig...

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Bibliographic Details
Published in:Therapeutic delivery 2019-09, Vol.10 (9), p.585-597
Main Authors: Jadhav, Pankaj A, Yadav, Adhikrao V
Format: Article
Language:English
Subjects:
Bioavailability
Cornea
Design of experiments
Drug delivery
Drug delivery systems
Drugs
Entrapment
Hydration
ketorolac tromethamine
lyophilization
Nanocrystals
Nanoparticles
nanoprecipitation
nanosuspension
Particle size
Permeability
Polymers
Polyvinyl alcohol
probe sonication
Research methodology
Researchers
Sonication
Studies
Surfactants
Variables
Viscosity
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Summary:At present, various ophthalmic formulations show low bioavailability. The rationale of present work was to design and develop stable ketorolac tromethamine nanosuspension with sustained effect and greater permeability for ocular drug delivery and increased ocular residence.   Formulations were designed by using central composite design, developed by combined nanoprecipitation and probe sonication method. Nanosuspensions depicted the size range of the particles in between 199 and 441 nm with slight reduction in crystallinity of drug. drug release revealed that higher % entrapment efficiency of drug in nanosuspension delays the drug release. Eudragit RL-100-based nanosuspension increases viscosity and avoids problems like drug loss from precorneal surface and rapid drainage through nasolacrimal areas.
ISSN:2041-5990
2041-6008
DOI:10.4155/tde-2019-0045