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Palladium‐Catalyzed Selective Synthesis of Dibenzoazepin‐5‐ols and Benzopyridoazepin‐5‐ols
An efficient palladium‐catalyzed tandem addition/cyclization of 2′‐formyl‐[1,1′‐biaryl]‐2‐carbonitriles with arylboronic acids is reported. This reaction affords dibenzo[c,e]azepin‐5‐ols and benzo[c]pyrido[2,3‐e]azepin‐5‐ols with excellent selectivity and wide functional group compatibility. The dib...
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Published in: | Advanced synthesis & catalysis 2019-10, Vol.361 (20), p.4707-4713 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | An efficient palladium‐catalyzed tandem addition/cyclization of 2′‐formyl‐[1,1′‐biaryl]‐2‐carbonitriles with arylboronic acids is reported. This reaction affords dibenzo[c,e]azepin‐5‐ols and benzo[c]pyrido[2,3‐e]azepin‐5‐ols with excellent selectivity and wide functional group compatibility. The dibenzo[c,e]azepin‐5‐ols show good cell growth inhibitory activity against a triple‐negative breast cancer cell line. Moreover, the proposed mechanistic rationale for this tandem process is supported by theoretical calculations. |
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ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201900705 |