Clinical stage and risk of recurrence and mortality: interaction of DNA methylation factors in patients with colorectal cancer

Aberrant DNA methylation plays a crucial role in cancer development; however, prospective evidence of an interaction between molecular biomarkers and cancer staging for predicting the prognosis of colorectal cancer (CRC) is still limited. We examined DNA methylation in tumors and adjacent normal tis...

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Bibliographic Details
Published in:Journal of investigative medicine 2016-10, Vol.64 (7), p.1200-1207
Main Authors: Chang, Hsien-Feng, Wu, Chang-Chieh, Sun, Chien-An, Chu, Chi-Ming, Lin, Fu-Gong, Hsieh, Jih-Fu, Hsu, Chih-Hsiung, Huang, Chi-Hua, Yang, Tsan, Tsai, Yang-Ming, Kuan, Jen-Chun, Chou, Yu-Ching
Format: Article
Language:English
Subjects:
Aged
Binding sites
Biomarkers
Cell cycle
Clinical medicine
Colorectal cancer
Colorectal Neoplasms - genetics
Colorectal Neoplasms - mortality
Colorectal Neoplasms - surgery
Cyclin-dependent kinases
Deoxyribonucleic acid
DNA
DNA methylation
DNA Methylation - genetics
Epigenetics
Female
Gene expression
Humans
Kinases
Male
Medical prognosis
Medical records
Metastasis
Middle Aged
Mortality
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - mortality
Neoplasm Staging
Odds Ratio
Promoter Regions, Genetic
Public health
Risk Factors
Studies
Surgery
Tumors
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Summary:Aberrant DNA methylation plays a crucial role in cancer development; however, prospective evidence of an interaction between molecular biomarkers and cancer staging for predicting the prognosis of colorectal cancer (CRC) is still limited. We examined DNA methylation in tumors and adjacent normal tissues from patients who underwent CRC surgical resection, and evaluated the interaction between cancer staging (advanced vs local) and DNA methylation to predict the prognosis of CRC. We recruited 132 patients with CRC from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select 3 tumor suppressor genes involved in carcinogenesis pathways. ORs and 95% CIs were computed using logistic regression analyses while adjusting for potential covariates. Advanced cancer stage was correlated with cancer recurrence (OR 7.22, 95% CI 2.82 to 18.45; p
ISSN:1081-5589
1708-8267
DOI:10.1136/jim-2016-000086