Autoantibodies directed against tyrosyl-tRNA synthetase modulate its aminoacylating activity

The autoantibodies directed against many proteins and ribonucleoproteids, the components of translation apparatus, have been detected at several systemic autoimmune diseases. Earlier we revealed the autoantibodies against seryl-tRNA synthetase in the blood sera of patients with systemic lupus erythe...

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Bibliographic Details
Published in:Biopolimery i kletka 1996, Vol.12 (5), p.21-28
Main Authors: Sidorik, L. L., Rodnin, N. V., Savinskaya, L. A., Ribkinska, T. A., Rozhko, O. T., Korneliuk, A. I., Matsuka, G. H.
Format: Article
Language:English
Subjects:
Autoantibodies
Autoimmune diseases
Rheumatoid arthritis
Serine-tRNA ligase
Systemic lupus erythematosus
Translation
tRNA
Tyrosine-tRNA ligase
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Summary:The autoantibodies directed against many proteins and ribonucleoproteids, the components of translation apparatus, have been detected at several systemic autoimmune diseases. Earlier we revealed the autoantibodies against seryl-tRNA synthetase in the blood sera of patients with systemic lupus erythematosus and rheumatoid arthritis. In the present paper we report about the autoantibodies directed against tyrosyl-tRNA synthetase, the other translation apparatus component. While the polyclonal antibodies inhibited the aminoacylating activity of TyrRS down to 30 % the autoantibodies from autoimmune sera activated it up to 280 % that hasn't been observed for any other synthetase. The possible reasons of this phenomenon are discussed.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.000444