The start of systems biology in Ukraine

The first laboratory of Systems Biology in Ukraine (IMBIG NASU) represents a track record of its scientific results. They include the pioneered development of a web-based tool for genome-wide surveys of eukaryotic promoters for the presence of transcription factors binding sites (COTRASIF); the deci...

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Bibliographic Details
Published in:Biopolimery i kletka 2015, Vol.30 (1), p.16-24
Main Authors: Obolenskaya, M. Yu, Tokovenko, B. T., Kuklin, A. V., Frolova, A. A., Rodriguez, R. R., Dotsenko, V. A., Dragushchenko, O. O.
Format: Article
Language:English
Subjects:
Binding sites
Folic acid
Genomes
Hepatectomy
Hepatocytes
Interferon
Placenta
Transcription factors
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Summary:The first laboratory of Systems Biology in Ukraine (IMBIG NASU) represents a track record of its scientific results. They include the pioneered development of a web-based tool for genome-wide surveys of eukaryotic promoters for the presence of transcription factors binding sites (COTRASIF); the deciphered mechanisms of the fine-tuned and balanced response of primary hepatocytes to interferon alpha levels recorded after partial hepatectomy; the elaboration of a novel method of gene regulatory network inference compatible with GRID environment and the development of a stoichiometric model of folate-related one carbon unit metabolism in human placenta and its application for the characteristics of the system’s behavior as a whole at different human pathologies.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.000878