What is killing people with hepatitis C virus infection? Analysis of a population-based cohort in Canada

Background: Persons with hepatitis C virus (HCV) infection are at risk of mortality from both chronic liver disease and HCV acquisition risk activities. We compared causes of death among HCV positive and negative individuals to characterize contributions of acquisition risks and viral sequelae. Meth...

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Bibliographic Details
Published in:The International journal of drug policy 2019-10, Vol.72, p.114
Main Authors: Krajden, Mel, Cook, Darrel A, Wong, Stanley, Yu, Amanda, Butt, Zahid A, Rossi, Carmine, Darvishian, Maryam, Alvarez, Maria, Buxton, Jane A, Tyndall, Mark, Janjua, Naveed Z
Format: Article
Language:English
Subjects:
Acquisition
Antiviral drugs
Childbirth & labor
Death & dying
Drug overdose
Drug policy
Hepatitis
Hepatitis C
Infections
Killing
Liver diseases
Mortality
Opioids
Public health
Risk
Uptake
Viruses
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Summary:Background: Persons with hepatitis C virus (HCV) infection are at risk of mortality from both chronic liver disease and HCV acquisition risk activities. We compared causes of death among HCV positive and negative individuals to characterize contributions of acquisition risks and viral sequelae. Methods: The British Columbia (BC) Hepatitis Testers Cohort (BC-HTC) includes all individuals tested for HCV or reported as a HCV case since 1992, linked to health administrative data. ICD-10 codes were used to classify deaths as: 1) liver-related (LR); 2) HCV acquisition risk-related (AR); and 3) other causes. Mortality proportions and trends were assessed among HCV positive and negative individuals overall and by birth cohort (born
ISSN:0955-3959
1873-4758
DOI:10.1016/j.drugpo.2019.02.013