Activiation of G551D CFTR channel with MPB-91: Regulation by ATPase activity and phosphorylation

We have designed and synthesized benzo[c]quinolizinium derivatives and evaluated their effects on the activity of G551D cystic fibrosis transmembrane conductance regulator (CFTR) expressed in Chinese hamster ovary and Fisher rat thyroid cells.

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2001-11, Vol.50 (5), p.C1657
Main Authors: Derand, Renaud, Bulteau-Pignoux, Laurence, Mettey, Yvette, Zegarra-Moran, Olga
Format: Article
Language:English
Subjects:
Cystic fibrosis
Mutation
Pharmacology
Regulation
Rodents
Online Access:Get full text
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Description
Summary:We have designed and synthesized benzo[c]quinolizinium derivatives and evaluated their effects on the activity of G551D cystic fibrosis transmembrane conductance regulator (CFTR) expressed in Chinese hamster ovary and Fisher rat thyroid cells.
ISSN:0363-6143
1522-1563