Cloning and characterization of a functional P2X receptor from larval bullfrog skin

ATP activates an apical-to-basolateral nonselective cation current across the skin of larval bullfrogs (Rana catesbeiana) with similarities to currents carried by some P2X receptors. A functional P2X receptor was cloned from tadpole skin RNA that encodes a 409-amino acid protein with highest protein...

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Bibliographic Details
Published in:American Journal of Physiology: Cell Physiology 2001-09, Vol.50 (3), p.C954-C962
Main Authors: JENSIK, Philip J, HOLBIRD, Doyle, COLLARD, Michael W, COX, Thomas C
Format: Article
Language:English
Subjects:
Adenosinic and purinergic receptors
Amino acids
Biological and medical sciences
Cell receptors
Cell structures and functions
Cloning
Frogs
Fundamental and applied biological sciences. Psychology
Molecular and cellular biology
Ribonucleic acid
RNA
Skin
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Summary:ATP activates an apical-to-basolateral nonselective cation current across the skin of larval bullfrogs (Rana catesbeiana) with similarities to currents carried by some P2X receptors. A functional P2X receptor was cloned from tadpole skin RNA that encodes a 409-amino acid protein with highest protein homology to cP2Xs.
ISSN:0363-6143
1522-1563